Intracytoplasmic sperm injection is a next-level IVF treatment and a form of ART-assisted reproductive technology. ICSI is used as a complementary treatment to in vitro fertilization (IVF) to treat infertility problems and disorders. For repeatedly failed IVF cycles, ICSI is used as a treatment to overcome male infertility problems. In the ICSI procedure, the sperm for fertilization is injected directly into the female egg during IVF treatment.
 ICSI treatment is used in cases where the male partner experiences: 
• Low sperm count 
• Ejaculation problems
 • Presence of high levels of antibodies in semen 
• Poor sperm quality • Failure of conventional IVF cycles 
• An unusually high percentage of morphologically abnormal sperm In Vitro Fertilization (IVF) versus intracytoplasmic sperm injection (ICSI) For patients, in vitro fertilization and intracytoplasmic sperm injection are the same treatments to treat infertility problems. From a medical point of view, conventional IVF is a treatment in which the sperm naturally fertilizes an egg, while the ICSI procedure is an advanced IVF treatment to treat male infertility. ICSI treatment is performed in clinical laboratories and under the supervision of trained infertility specialists. 
• The semen sample is taken from the male epididymis and the ova from the uterus. 
• Then, using a small glass needle, sperm is injected into the egg.
 • The fertilized egg is then stored to observe its growth and development. 
• The embryo is successfully implanted in the uterus to have a better chance of conception. IVF ICSI Cost Success Rate in India The IVF ICSI success rate in India can range from 65% to 75% on average which varies from place to place. As the success rate of IVF-ICSI treatment increases, the cost of IVF-ICSI in India will increase. Other factors that can affect the cost of IVF ICSI in India can be the doctor’s success rate, medical history of pregnancy, and miscarriage. Benefits of IVF-ICSI Treatment Each infertility treatment for infertile couples has its unique benefits in the medical field. The same applies to IVF-ICSI treatment. ICSI IVF treatment is most beneficial for infertile couples where traditional IVF cycles, IUI treatments, and low sperm counts have failed repeatedly, leading to failure of conception, poor sperm motility, physical blockage, and other similar infertility problems. List of Things Not to Do During IVF ICSI Treatment
• Tobacco and Smoking: The infertility specialist always recommends that the couple stop smoking or tobacco use before starting the IVF ICSI treatment cycle. Tobacco leaves a drastic effect on a woman’s egg cells and is considered unhealthy and toxic.
IVF with ICSI What are the risks?
1. Multiple pregnancies: Infertile couples who use ICSI in addition to IVF treatment have an increased risk of multiple pregnancies. According to IVF specialists in IVF centers in India, there is a 30-35% chance of having twins and around 5-10% chance of having triplets and more. The multiple can lead to pregnancy complications such as gestational diabetes, high blood pressure, cesarean section, and premature birth.
2. Risk of Birth Defects: Although there is less chance of birth defects in a child conceived by ICSI, couples should be aware of these risks before booking an appointment at an IVF center in India. Risks of birth defects include hypospadias and sex chromosome abnormalities.
3. Damage to the female ovum: At the time of sperm injection, there is a risk of damaging the female ovum, which can lead to abnormal growth and the development of offspring.